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CSS 650. Advanced Plant Breeding and Quantitative Genetics

Date

Topic

Related Files

Sept. 24 Introduction  
Sept. 26

Population Genetics
Lecture 1: Gene and genotype frequencies, one and two locus equilibrium

FisherExact.xls
HardyTest.xls
Sept. 28 Lecture 2: Small populations, inbreeding and coancestry Tabular.xls
Oct. 1 Lecture 3: Changes in gene frequency due to selection selection.xls
Oct. 8 Quantitative Genetics
Lecture 4: Genotypic values, Average effect of a gene, Breeding values
Epistasis.xls
Oct. 10 Lecture 5: Genetic variances: additive and dominance Regression.xls
Oct. 15 Lecture 6: Environmental variance, heritability  
Oct. 17 Lecture 7: Estimating genetic variances, Part I.  
Oct. 19 Lecture 8: Part II: Nested and Diallel Designs  

Oct. 31

Selection
Lecture 9: BLUP for purelines

BLUPpurelines.xls
Nov. 7 Lecture 10: BLUP for single-crosses
 
Nov. 2 Lecture 11:Recurrent Selection  
Nov. 9 Lecture 12: Genetic correlations, Index Selection twotraits.xls
Nov. 12 Lecture 13: Marker Assisted Selection  
Nov. 19 Lecture 14: Inbreeding and Hybridization  

Nov. 16

Breeding for Diverse Environments
Lecture 15: Multilocational Trials and GXE

 
Nov. 21 Lecture 16: Genomic and Metabolomic Resources for Crop Improvement; Case Study of Glucosinolates (Guest lecture by Mary Slabaugh)  

Lecture Schedule

Week

Topic

1

Breeding Populations and Mating Systems

 

  • Gene and genotype frequencies in random mating populations (Hardy-Weinberg equilibrium and assumptions)
  • Two loci (gametic phase equilibrium)
  • Changes in gene frequency due to selection
  • Coancestry and inbreeding
    • From pedigrees
    • Regular systems of inbreeding

3

Quantitative Genetics – Mean Performance of Populations

 

  • Components of phenotypes
  • Genotypic values
  • Average effect of a gene
  • Breeding values
  • Selection of parents

4

Quantitative Genetics – Phenotypic and Genetic Variances

 
  • Genetic variance: additive and dominance
  • Environmental variance
  • Covariance between relatives
  • Heritability
  • Genetic and phenotypic correlations

5-6

Estimation of Genetic Parameters

 

  • Variance components
    • From paired matings and other family structures used in breeding programs
    • North Carolina Designs I, II, III
    • Parent-offspring regression
    • Generation means analysis
    • Realized heritability from selection experiments
    • Designs for detecting epistasis
    • Complex pedigrees – BLUP, ML vs REML estimation
  • GCA and SCA
    • Diallel analyses
    • Testcross trials (progeny trials)
  • Degree of dominance, heterosis, inbreeding depression

7-8

Selection Response

 
  • Expected gain from selection
  • Breeding inbred lines and hybrids: testcross selection, predicting performance of hybrids and synthetics
  • Family index - combining information from relatives
  • Selection for multiple traits (other types of selection indices)
  • Indirect selection with correlated characteristics
  • Marker assisted selection

9

Breeding for Diverse Environments

 
  • The concepts of stability, specific adaptation, and broad adaptation
  • Analysis of genotype by environment interactions

9-10

Breeding for Stress Tolerance – Case Studies

 
  • Breeding for Abiotic Stress Tolerance (nitrogen use efficiency in maize)
  • Presentation of group projects

 


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Last updated March 1, 2005